Post-Doctoral Fellowship, University of Rochester
Ph.D., University of Rochester
M.S., University of Rochester
B.S., Pacific University (OR)
Dr. Sapinoro received his B.S. in biology from Pacific University (Forest Grove, OR) and received a Ph.D. in microbiology and immunology from the University of Rochester School of Medicine and Dentistry (Rochester, NY), where he was awarded a Provost’s Fellowship. Prior to joining the Department of Pharmaceutical Sciences as an Assistant Professor in the summer of 2010, Dr. Sapinoro served as an Adjunct Professor at the Wegmans School of Pharmacy and continued his research interests as a Post-Doctoral Research Fellow at the University of Rochester.
Dr. Sapinoro's cross-disciplinary research interests translates his extensive training in immunology and environmental toxicology to focus on investigating the influence of endogenous lipid mediators in the regulation of cells involved in innate and adaptive immune responses. The ability of bioactive lipid mediators to regulate immune cell function may be a therapeutic avenue to treat diseases associated with autoimmunity, chronic inflammation, or influence the efficacy of vaccinations. Overall, the goals of this research are to gain a better understanding of the cellular and molecular mechanisms involved in the actions of different families of endogenous bioactive lipid mediators, and to translate this information towards the development of novel therapies.
While performing Post-Doctoral research at the University of Rochester, Dr. Sapinoro received Fellowship Training awards in Viral Diseases, Vaccines, and Bio-defense, and Environmental Toxicology. In 2010, Dr. Sapinoro was award the American Thoracic Society Minority Trainee Award. In addition, he and his Post-Doctoral advisor received an institutional Pilot Collaborative Grant from the Clinical and Translational Science Institute at the University of Rochester. His novel research results have been recognized and published in top-rated journals in his field of study, and presented at numerous conferences, including the American Society of Gene Therapy, American Thoracic Society, and AIDS Vaccine.
Outside of research, Dr. Sapinoro is involved in the PETAL Learning Circles, and promotes active learning to foster critical thinking and understanding. His teaching philosophy engages students to expand their understanding into paradigms involving their personal lives and future careers. Dr. Sapinoro has translated his thesis work to develop an AIDS Vaccine Case Study incorporating an active learning model which was presented at the National Association of Biology Teachers Annual Conference.
- Sapinoro R, Levy E, Serhan CN, Phipps RP, Sime PJ. 2010. The Anti-inflammatory and Pro-resolving Lipid Mediator Resolvin D1 Regulates Cigarette Smoke-induced Lung Inflammation In vitro and In vivo. (Manuscript in preparation)
- Hogan CM, Sapinoro R, Gurell M, Pollack SJ, Phipps RP, Sime PJ. 2010. Electrophilic PPARg ligands attenuate IL-1b and silica induced lung inflammation in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol (In press)
- Sapinoro R, Rodrigo S, Schlesinger J, Dewhurst S. 2007. Fc receptor mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells. Virology. 2008 Apr 10;373(2):274-86. Epub 2008 Jan 14. [PMID: 18991979]
- Sapinoro R, Maguire C, Burgess A, Dewhurst S. 2007. Enhanced transduction of dendritic cells by FcgRI-targeted adenovirus. J Gene Med. 2007 Dec;9(12):1033-45. [PMID: 17966114]
- Zanghi CN, Sapinoro R, Bradel-Tretheway B, Dewhurst S. 2007. A tractable method for simultaneous modifications to the head and tail of bacteriophage lambda and its application to enhancing phage-mediated gene delivery. Nucleic Acids Res. 35(8):e59. [PMID: 17392341]
- Maguire CA, Sapinoro R, Girgis N, Rodriguez-Colon SM, Ramirez SH, Williams J, Dewhurst S. 2006. Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigens. Vaccine. Jan 30;24(5):671-82. [PMID: 16154247]
- Fan S, Maguire CA, Ramirez SH, Bradel-Tretheway B, Sapinoro R, Sui Z, Chakraborty-Sett S, Dewhurst S. 2005. Valproic acid enhances gene expression from viral gene transfer vectors. J Virol Methods. 125(1): 23-33. [PMID: 15737413]
- Wang X, Messerle M, Sapinoro R, Santos K, Hocknell PK, Jin X, Dewhurst S. 2003. Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes. J Virol. 77(13): 7182-92. [PMID: 12805417]